β‑Diketonate-Iron(III) Complex: A Versatile Fluorine-19 MRI Signal Enhancement Agent.

ABSTRACT: Fluorine-19 magnetic resonance imaging (MRI) has gained considerable momentum as a promising imaging modality for in vivo tracking of cellular therapies and as a diagnostic for inflammatory disease. To further the utility of this technique, we increase imaging probe sensitivity by merging paramagnetic metal chelates with aqueous perfluorocarbon (PFC) nanoemulsions. We prepared a highly fluorinated ferric tris(β-diketonate) chelate (MW = 1265.2 g/mol) at gram scale. This iron chelate is soluble in multiple PFC oils used for MRI and readily reduces the ¹⁹F longitudinal relaxation time (T ₁) to <100 ms with modest line broadening and displays superior properties for ¹⁹F MRI applications. The sensitivity enhancement by Fe(III) laden PFC nanoemulsi

SUBMITTER: Wang C 

PROVIDER: S-EPMC8112722 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature