APOE ε4 alters associations between docosahexaenoic acid and preclinical markers of Alzheimer's disease.

ABSTRACT: Docosahexaenoic acid is the main long-chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30-40% of fatty acids in the grey matter of the human cortex. Although the influence of docosahexaenoic acid on memory function is widely researched, its association with brain volumes is under investigated and its association with spatial navigation is virtually unknown. This is despite the fact that spatial navigation deficits are a new cognitive fingerprint for symptomatic and asymptomatic Alzheimer's disease. We investigated the cross-sectional relationship between docosahexaenoic acid levels and the major structural and cognitive markers of preclinical Alzheimer's disease, namely hippocampal volume, entorhinal volume and spatial navigation ability. Fifty-three cognitively norm

SUBMITTER: Coughlan G 

PROVIDER: S-EPMC8112902 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature