Impairment of visual cortical plasticity by amyloid-beta species.

ABSTRACT:

Introduction

A variety of transgenic and knock-in mice that express mutant alleles of Amyloid precursor protein (APP) have been used to model the effects of amyloid-beta (Aβ) on circuit function in Alzheimer's disease (AD); however phenotypes described in these mice may be affected by expression of mutant APP or proteolytic cleavage products independent of Aβ. In addition, the effects of mutant APP expression are attributed to elevated expression of the amyloidogenic, 42-amino acid-long species of Aβ (Aβ42) associated with amyloid plaque accumulation in AD, though elevated concentrations of Aβ40, an Aβ species produced with normal synaptic activity, may also affect neural function.

Methods

To explore the effects of elevated expression of Aβ on synaptic function in vivo, we a

SUBMITTER: William CM 

PROVIDER: S-EPMC8113107 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature