Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds.

ABSTRACT: Cancer is the second deadliest disease worldwide. Although recent advances applying precision treatments with targeted (molecular and immune) agents are promising, the histological and molecular heterogeneity of cancer cells and huge mutational burdens (intrinsic or acquired after therapy) leading to drug resistance and treatment failure are posing continuous challenges. These recent advances do not negate the need for alternative approaches such as chemoprevention, the pharmacological approach to reverse, suppress or prevent the initial phases of carcinogenesis or the progression of premalignant cells to invasive disease by using non-toxic agents. Although data are limited, the success of several clinical trials in preventing cancer in high-risk populations suggests that chemoprevention i

SUBMITTER: Haque A 

PROVIDER: S-EPMC8113151 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature