Predicting tumor response and outcome of second-look surgery with ¹⁸F-FDG PET/CT: insights from the GINECO CHIVA phase II trial of neoadjuvant chemotherapy plus nintedanib in stage IIIc-IV FIGO ovarian cancer.

ABSTRACT:

Background

This ancillary study aimed to evaluate ¹⁸F-FDG PET parameter changes after one cycle of treatment compared to baseline in patients receiving first-line neoadjuvant anti-angiogenic nintedanib combined to paclitaxel-carboplatin chemotherapy or chemotherapy plus placebo and to evaluate the ability of ¹⁸F-FDG PET parameters to predict progression-free survival (PFS), overall survival (OS), and success of second-look surgery.

Materials and methods

Central review was performed by two readers blinded to the received treatment and to the patients' outcome, in consensus, by computing percentage change in PET metrics within a volume of interest encompassing the entire tumor burden. EORTC and PERCIST criteria were applied to classify patients as respond

SUBMITTER: Aide N 

PROVIDER: S-EPMC8113167 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature