Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature.

ABSTRACT: Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neuromuscular signaling due to autoantibodies targeting the acetylcholine receptor. Although its auto-antigens and effector mechanisms are well defined, the cellular and molecular drivers underpinning MG remain elusive. Here, we employed high-dimensional single-cell mass and spectral cytometry of blood and thymus samples from MG patients in combination with supervised and unsupervised machine-learning tools to gain insight into the immune dysregulation underlying MG. By creating a comprehensive immune map, we identified two dysregulated subsets of inflammatory circulating memory T helper (Th) cells. These signature Th_CD103 and Th_GM cells populated the diseased thymus, were reduced in the blood o

SUBMITTER: Ingelfinger F 

PROVIDER: S-EPMC8113175 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature