Rethinking the Application of Pemetrexed for Patients with Renal Impairment: A Pharmacokinetic Analysis.

ABSTRACT:

Background

Pemetrexed is used for the treatment for non-small cell lung cancer and mesothelioma. Patients with renal impairment are withheld treatment with this drug as it is unknown what dose is well tolerated in this population.

Objective

The purpose of our study was to investigate the pharmacokinetics (PK) of pemetrexed in patients with renal impairment.

Methods

A population PK analysis of pemetrexed was performed using non-linear mixed-effects modelling with phase I data obtained from the manufacturer. Additionally, the impact of renal function on pemetrexed PK was assessed with a simulation study using the developed PK model and a previously developed PK model lacking the phase I data.

Results

The dataset included 548 paired observations of 47 patients, wi

SUBMITTER: de Rouw N 

PROVIDER: S-EPMC8113206 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature