Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography.

ABSTRACT:

Purpose

Cervical cancer metabolic tumour volume (MTV) derived from [18F]-FDG PET/CT has a role in prognostication and therapy planning. There is no standard method of outlining MTV on [18F]-FDG PET/CT. The aim of this study was to assess the optimal method to outline primary cervical tumours on [18F]-FDG PET/CT using MRI-derived tumour volumes as the reference standard.

Methods

81 consecutive cervical cancer patients with pre-treatment staging MRI and [18F]-FDG PET/CT imaging were included. MRI volumes were compared with different PET segmentation methods. Method 1 measured MTVs at different SUV_max thresholds ranging from 20 to 60% (MTV₂₀-MTV₆₀) with bladder masking and manual adjustment when required. Method 2 created an isocontour around th

SUBMITTER: Arshad MA 

PROVIDER: S-EPMC8113292 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature