Clinically feasible semi-automatic workflows for measuring metabolically active tumour volume in metastatic melanoma.

ABSTRACT:

Purpose

Metabolically active tumour volume (MATV) is a potential quantitative positron emission tomography (PET) imaging biomarker in melanoma. Accumulating data indicate that low MATV may predict increased chance of response to immunotherapy and overall survival. However, metastatic melanoma can present with numerous (small) tumour lesions, making manual tumour segmentation time-consuming. The aim of this study was to evaluate multiple semi-automatic segmentation workflows to determine reliability and reproducibility of MATV measurements in patients with metastatic melanoma.

Methods

An existing cohort of 64 adult patients with histologically proven metastatic melanoma was used in this study. ¹⁸F-FDG PET/CT diagnostic baseline images were acquired using a European

SUBMITTER: van Sluis J 

PROVIDER: S-EPMC8113298 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature