Diagnosing Transthyretin Cardiac Amyloidosis by Technetium Tc 99m Pyrophosphate: A Test in Evolution.

ABSTRACT:

Objectives

This study aimed to characterize trends in technetium Tc 99m pyrophosphate (^99mTc-PYP) scanning for amyloid transthyretin cardiac amyloidosis (ATTR-CA) diagnosis, to determine whether patients underwent appropriate assessment with monoclonal protein and genetic testing, to evaluate use of single-photon emission computed tomography (SPECT) in addition to planar imaging, and to identify predictive factors for ATTR-CA.

Background

^99mTc-PYP scintigraphy has been repurposed for noninvasive diagnosis of ATTR-CA. Increasing use of ^99mTc-PYP can facilitate identification of ATTR-CA, but appropriate use is critical for accurate diagnosis in an era of high-cost targeted therapeutics.

Methods

Patients undergoing ^99mTc-PYP sc

SUBMITTER: Poterucha TJ 

PROVIDER: S-EPMC8113330 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature