Relationship between markers of inflammation and hemodynamic stress and death in patients with out-of-hospital cardiac arrest.

ABSTRACT: Biomarkers that reflect hemodynamic stress, inflammation, extracellular matrix remodeling, angiogenesis, and endothelial dysfunction may improve risk stratification and add valuable pathobiological insight in patients with out-of-hospital cardiac arrest (OHCA). In total, 120 patients with OHCA who survived at least 48 h after return of spontaneous circulation were consecutively included in the present analysis. Concentrations of 30 biomarkers were measured simultaneously using a multi-panel biomarker assay. Cox regression models were adjusted for age, sex, estimated glomerular filtration rate, lactate concentration, bystander resuscitation, initial cardiac rhythm, and type of targeted temperature management. Overall, 57 patients (47.5%) had a favorable neurological outcome (Cerebral Perfor

SUBMITTER: Zelniker TA 

PROVIDER: S-EPMC8113496 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature