Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.

ABSTRACT: Efficient immune responses rely on heterogeneity, which in CD8⁺ T cells, amongst other mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing, known to negatively impact immune responses, impairs ACD in murine CD8⁺ T cells, and that this phenotype can be rescued by transient mTOR inhibition. Increased ACD rates in mitotic cells from aged mice restore the expansion and memory potential of their cellular progenies. Further characterization of the composition of CD8⁺ T cells reveals that virtual memory cells (T_VM cells), which accumulate during ageing, have a unique proliferation and metabolic profile, and retain their ability to divide asymmetrically, which correlates with increased memory potential. The opposite is obs

SUBMITTER: Borsa M 

PROVIDER: S-EPMC8113513 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature