Intra-host evolutionary dynamics of the hepatitis C virus among people who inject drugs.

ABSTRACT: Most individuals chronically infected with hepatitis C virus (HCV) are asymptomatic during the initial stages of infection and therefore the precise timing of infection is often unknown. Retrospective estimation of infection duration would improve existing surveillance data and help guide treatment. While intra-host viral diversity quantifications such as Shannon entropy have previously been utilized for estimating duration of infection, these studies characterize the viral population from only a relatively short segment of the HCV genome. In this study intra-host diversities were examined across the HCV genome in order to identify the region most reflective of time and the degree to which these estimates are influenced by high-risk activities including those associated with HCV acquisitio

SUBMITTER: Montoya V 

PROVIDER: S-EPMC8113533 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature