Identification of linear epitopes on the flagellar proteins of Clostridioides difficile.

ABSTRACT: Clostridioides difficile (C. difficile) is an opportunistic anaerobic bacterium that causes severe diseases of the digestive tract of humans and animals. One of the possible methods of preventing C. difficile infection is to develop a vaccine. The most promising candidates for vaccine antigens are the proteins involved in the adhesion phenomena. Among them, the FliC and FliD are considered to be suitable candidates. In this paper, the FliC and FliD protein polypeptide epitopes were mapped in silico and by using PEPSCAN procedure. We identified four promising epitopes: ¹¹⁷QRMRTLS¹²³, ²⁰⁵MSKAG²⁰⁹ of FliC and ²²⁶NKVAS²³⁰, ³⁰⁶TTKKPKD³¹² of FliD protein. We showed that ¹¹⁷QRMRTLS¹²³ seq

SUBMITTER: Razim A 

PROVIDER: S-EPMC8113543 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature