Three-Dimensional Model of Sub-Plasmalemmal Ca²⁺ Microdomains Evoked by the Interplay Between ORAI1 and InsP₃ Receptors.

ABSTRACT: Ca²⁺ signaling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca²⁺ microdomains characterized by reduced spatial and temporal extents are observed in the junctions between the plasma membrane (PM) and the endoplasmic reticulum (ER). Such Ca²⁺ responses can also occur in response to T cell adhesion to other cells or extracellular matrix proteins in otherwise unstimulated T cells. These non-TCR/CD3-dependent Ca²⁺ microdomains rely on d-myo-inositol 1,4,5-trisphosphate (IP₃) signaling and subsequent store operated Ca²⁺ entry (SOCE) via the ORAI/STIM system. The detailed molecular mechanism of

SUBMITTER: Gil D 

PROVIDER: S-EPMC8113648 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature