Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake.

ABSTRACT: Parvalbumin (PV) is a cytosolic Ca²⁺-binding protein highly expressed in fast skeletal muscle, contributing to an increased relaxation rate. Moreover, PV is an "atrogene" downregulated in most muscle atrophy conditions. Here, we exploit mice lacking PV to explore the link between the two PV functions. Surprisingly, PV ablation partially counteracts muscle loss after denervation. Furthermore, acute PV downregulation is accompanied by hypertrophy and upregulation by atrophy. PV ablation has a minor impact on sarcoplasmic reticulum but is associated with increased mitochondrial Ca²⁺ uptake, mitochondrial size and number, and contacts with Ca²⁺ release sites. Mitochondrial calcium uniporter (MCU) silencing abolishes the hypertrophic effect of PV ablation, sugge

SUBMITTER: Butera G 

PROVIDER: S-EPMC8113653 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature