The proteomic data of liver in mice with hyperlipidemia.

ABSTRACT: Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), lower high-density lipoprotein (HDL) and atherosclerotic index (ASI) in mice were analyzed under the action of FRR juice. Then differentially expressed proteins in liver were further analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice [8]. After the protein extraction and trypsin digestion, TMT labeling proteomic analysis were performed. The

SUBMITTER: Song P 

PROVIDER: S-EPMC8113717 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature