Monocytic-Myeloid Derived Suppressor Cells of HIV-Infected Individuals With Viral Suppression Exhibit Suppressed Innate Immunity to Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis can occur during any stage of Human Immunodeficiency virus 1 (HIV) -infection including times when CD4⁺ T cell numbers have reconstituted and viral replication suppressed. We have previously shown that CD11b⁺CD33⁺CD14⁺HLA-DR^-/lo monocytic myeloid-derived suppressor cells (MDSC) persist in HIV-infected individuals on combined anti-retroviral therapy (cART) and with virologic suppression. The response of MDSC to Mycobacterium tuberculosis (Mtb) is not known. In this study, we compared the anti-mycobacterial activity of MDSC isolated from HIV -infected individuals on cART with virologic suppression (HIV MDSC) and HIV-uninfected healthy controls (HIV (-) MDSC). Compared to HIV (-) MDSC, HIV MDSC produced significantly l

SUBMITTER: Namdev P 

PROVIDER: S-EPMC8113814 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature