Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

ABSTRACT:

Importance

Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis.

Objective

To assess the effect of antimicrobial therapy on clinical outcomes.

Design, setting, and participants

Pragmatic, randomized, unblinded clinical trial conducted across 35 US sites. A total of 513 patients older than 40 years were randomized from August 2017 to June 2019 (final follow-up was January 2020).

Interventions

Patients were randomized in a 1:1 allocation ratio to receive antimicrobials (n = 254) or usual care alone (n = 259). Antimicrobials included co-trimoxazole (trimethoprim 160 mg/sulfamethoxazole 800 mg twice daily plus folic acid 5 mg daily, n = 128) or doxycycline (100 mg once daily if body weight <50 kg or 100 mg twice daily

SUBMITTER: Martinez FJ 

PROVIDER: S-EPMC8114133 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature