Iron status and self-reported fatigue in blood donors.

ABSTRACT: Fatigue is a reported symptom of iron depletion, but studies in blood donors show no conclusive link. We conducted an observational analysis of data from the STRIDE randomized trial to evaluate association of iron status with self-reported fatigue.

Study design and methods

Three blood centers randomly assigned 692 frequent donors to education or iron supplementation treatments. Biomarkers for iron status were measured during 20 to 24 months of follow-up. A fatigue score was derived from an 11-item questionnaire at baseline and final visits, and associations between iron status and fatigue were assessed.

Results

Final lab and questionnaire data were evaluable from 337 subjects. At baseline, female sex, older age, and anemia were associated with fatigue, but iron status was not

SUBMITTER: Spencer BR 

PROVIDER: S-EPMC8114184 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature