The inhibitory effect of silencing CDCA3 on migration and proliferation in bladder urothelial carcinoma.

ABSTRACT:

Background

CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, however, its role in promoting human bladder urothelial carcinoma has not been fully elucidated.

Methods

Bioinformatic methods were used to analyze the expression level of CDCA3 in human bladder urothelial carcinoma tissues and the relationship between its expression level and key clinical characteristics. In vitro studies were performed to validate the specific functions of CDCA3 in regulating cell proliferation, cell migration and cell cycle process. Alterations of related proteins was investigated by western blot assays. In vivo studies were constructed to

SUBMITTER: Shen D 

PROVIDER: S-EPMC8114508 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature