BRAF^non-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAF^V600E but without a survival advantage.

ABSTRACT:

Background

The effects of BRAF^non-V600E and BRAF^V600E on the outcomes and the molecular characteristics of adult glioma patients are unknown and need to be explored, although BRAF^V600E has been extensively studied in pediatric glioma.

Methods

Co-occurring mutations and copy number alterations of associated genes in the MAPK and p53 pathways were investigated using data from The Cancer Genome Atlas (TCGA) public database retrieved by cBioPortal. The prognosis of available adult glioma cohorts with BRAF^V600E and BRAF^non-V600E mutations were also investigated.

Results

Ninety patients with BRAF^V600E or BRAF^non-V600E were enrolled in this study, and data from 52 nonredundant patients were investig

SUBMITTER: Wang W 

PROVIDER: S-EPMC8114535 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature