Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study.

ABSTRACT:

Background

This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).

Methods

This is a single-center prospective observational cohort study in COVID-19 patients with acute respiratory failure. Immediately after intensive care unit (ICU) admission patients were allocated to CVP treatment following pre-specified criteria to rapidly identify those patients potentially susceptible for this treatment. A propensity score adjustment [inverse probability of treatment weighted (IPTW) analysis] was implemented to account rigorously for imbalances in prognostic variables between the treatment groups.

Results

We included 120 patients of

SUBMITTER: Hatzl S 

PROVIDER: S-EPMC8114671 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature