A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation.

ABSTRACT:

Background

The temporal coordination of biological processes by the circadian clock is an important mechanism, and its disruption has negative health outcomes, including cancer. Experimental and theoretical evidence suggests that the oscillators driving the circadian clock and the cell cycle are coupled through phase locking.

Results

We present a detailed and documented map of known mechanisms related to the regulation of the circadian clock, and its coupling with an existing cell cycle map which includes main interactions of the mammalian cell cycle. The coherence of the merged map has been validated with a qualitative dynamics analysis. We verified that the coupled circadian clock and cell cycle maps reproduce the observed sequence of phase markers. Moreover, we predicted

SUBMITTER: Rougny A 

PROVIDER: S-EPMC8114686 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature