Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis.

ABSTRACT:

Background

Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis for five cannulation angles. With respect to the inflow cannula axis directed towards the mitral valve, the other angles were 25° and 20° towards the septum and 20° and 30° towards the free wall.

Results

Inflow cannula angulation towards the free wall resulted in longer blood residence time within the ventricle, slower ventricular washout and reduced pulsatility indices along

SUBMITTER: Neidlin M 

PROVIDER: S-EPMC8114696 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature