Subcutaneous vitamin B12 administration using a portable infusion pump in cobalamin-related remethylation disorders: a gentle and easy to use alternative to intramuscular injections.

ABSTRACT:

Background

Cobalamin (cbl)-related remethylation disorders are a heterogeneous group of inherited disorders comprising the remethylation of homocysteine to methionine and affecting multiple organ systems, most prominently the nervous system and the bone marrow. To date, the parenteral, generally intramuscular, lifelong administration of hydroxycobalamin (OHCbl) is the mainstay of therapy in these disorders. The dosage and frequency of OHCbl is titrated in each patient to the minimum effective dose in order to account for the painful injections. This may result in undertreatment, a possible risk factor for disease progression and disease-related complications.

Results

We describe parenteral administration of OHCbl using a subcutaneous catheter together with a portable infusio

SUBMITTER: Lotz-Havla AS 

PROVIDER: S-EPMC8114704 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature