Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS).

ABSTRACT:

Objective

To determine whether primary trabeculectomy or primary medical treatment produces better outcomes in term of quality of life, clinical effectiveness, and safety in patients presenting with advanced glaucoma.

Design

Pragmatic multicentre randomised controlled trial.

Setting

27 secondary care glaucoma departments in the UK.

Participants

453 adults presenting with newly diagnosed advanced open angle glaucoma in at least one eye (Hodapp classification) between 3 June 2014 and 31 May 2017.

Interventions

Mitomycin C augmented trabeculectomy (n=227) and escalating medical management with intraocular pressure reducing drops (n=226) MAIN OUTCOME MEASURES: Primary outcome: vision specific quality of life measured with Visual Function Questionnaire-25 (VF

SUBMITTER: King AJ 

PROVIDER: S-EPMC8114777 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature