Natriuretic Equation to Predict Loop Diuretic Response in Patients With Heart Failure.

ABSTRACT:

Background

Most acute decompensated heart failure admissions are driven by congestion. However, residual congestion is common and often driven by the lack of reliable tools to titrate diuretic therapy. The authors previously developed a natriuretic response prediction equation (NRPE), which predicts sodium output using a spot urine sample collected 2 h after loop diuretic administration.

Objectives

The purpose of this study was to validate the NRPE and describe proof-of-concept that the NRPE can be used to guide diuretic therapy.

Methods

Two cohorts were assembled: 1) the Diagnosing and Targeting Mechanisms of Diuretic Resistance (MDR) cohort was used to validate the NRPE to predict 6-h sodium output after a loop diuretic, which was defined as poor (<50 mmol), subopti

SUBMITTER: Rao VS 

PROVIDER: S-EPMC8114781 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature