Dataset Information

Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review.

ABSTRACT:

Objectives

Assessment of the impact of general anaesthetic agents on intraocular pressure (IOP) in children via systematic review.

Methods

Pubmed, Embase, and CENTRAL databases were systematically searched to identify randomised controlled trials, prospective, and interventional studies. The search included all studies through October 5, 2018 with no date or language restrictions. A linear mixed-effects regression analysis was performed to study the change in IOP after general anaesthesia (GA).

Results

The strategy identified 518 studies that met search criteria. Six studies (531 eyes) were included for quantitative synthesis. Seven categories of mixed and non-mixed induction and maintenance agents were compared. When assessing all agents utilising a model of mean IOP as a function of time, IOP decreased after induction phase at a rate of -0.59 ± 0.19 mmHg/min (P value = 0.006).

Conclusions

This systematic review showed that most anaesthetic agents significantly decrease IOP over time after the induction phase of general anaesthesia in children. An understanding of the effects of GA on IOP is critical for those performing paediatric ophthalmic examinations under anaesthesia.

SUBMITTER: Thanapaisal S

PROVIDER: S-EPMC8114907 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review.

Thanapaisal Sukhumal S Oatts Julius J Zhao Jing J Perez Claudio I CI Yang Yangfan Y Porco Travis C TC Singh Kuldev K Han Ying Y

Eye (London, England) 20200720 4

<h4>Objectives</h4>Assessment of the impact of general anaesthetic agents on intraocular pressure (IOP) in children via systematic review.<h4>Methods</h4>Pubmed, Embase, and CENTRAL databases were systematically searched to identify randomised controlled trials, prospective, and interventional studies. The search included all studies through October 5, 2018 with no date or language restrictions. A linear mixed-effects regression analysis was performed to study the change in IOP after general ana ...[more]

PMID: 32690926

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Project description:BackgroundTriamcinolone acetonide is a synthetic corticosteroid with multiple ocular uses. Like other corticosteroids, it too is associated with ocular side effects such as increased intraocular pressure (IOP), glaucoma and cataracts. Suprachoroidal administration of triamcinolone is hoped to reduce the ocular side effects of the drug, especially rises in IOP. Our systematic review and meta-analysis aims to study this phenomenon.ObjectivesThe purpose of this study was to evaluate the effect of suprachoroidal triamcinolone injections on IOP.DesignSystematic review and meta-analysis.MethodsWe utilized the Medline, Scopus and Cochrane databases for this review. Studies published till June 2023, which fulfilled the eligibility criteria, were included. Studies in the English language with adult participants who were administered suprachoroidal triamcinolone without any concurrent intervention were included, whereas studies that did not report the mean and standard deviation for IOP were excluded. The outcome of interest was IOP at 1, 3 and 6 months post-suprachoroidal triamcinolone injection. IOP values from included studies were extracted onto Review Manager version 5.4 for analysis.ResultsOur search yielded 104 results, from which 22 papers were shortlisted for full-text screening. Finally, 12 studies were included in the analysis. Our analysis suggests a statistically significant increase in IOP in the first month after suprachoroidal triamcinolone injection but no significant differences at 3 and 6 months post-injection as compared to baseline.ConclusionElevated IOP at 1 month post-injection must be considered when using suprachoroidal triamcinolone and adequate safety measures must be taken. However, the absence of a significant rise at 3 and 6 months post-injection indicates that this modality is safer than other existing drug delivery methods.Trial registrationRegistered with the Research Registry with the unique identifying number 'reviewregistry1656.' https://www.researchregistry.com/browse-the-registry#registryofsystematicreviewsmeta-analyses/registryofsystematicreviewsmeta-analysesdetails/648eefe65b6523002995eb21/.

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Dataset Information

Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review.

Objectives

Methods

Results

Conclusions

Publications

Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review.

Similar Datasets

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