Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.

ABSTRACT: Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a result, preexisting influenza-specific memory B cells can dominate the response after infection or vaccination. Memory B cells recalled by adulthood exposure are largely reactive to conserved viral epitopes present in childhood strains, posing unclear consequences on the ability of B cells to adapt to and neutralize newly emerged strains. We sought to investigate the impact of preexisting immunity on generation of protective antibody responses to conserved viral epitopes upon influenza virus infection and vaccination in humans. We accomplished this by characterizing monoclonal antibodies (mAbs) from plasmablasts, which are predominantly derived from preexisting memory B cells. We found that, wherea

SUBMITTER: Dugan HL 

PROVIDER: S-EPMC8115023 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature