Pharmacokinetic, behavioral, and brain activity effects of Δ⁹-tetrahydrocannabinol in adolescent male and female rats.

ABSTRACT: Δ⁹-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is responsible for the drug's reinforcing effects. Retrospective human studies suggest that cannabis use during adolescence is linked to long-term negative psychological outcomes, but in such studies it is difficult to distinguish the effects of THC from those of coexisting factors. Therefore, translationally relevant animal models are required to properly investigate THC effects in adolescents. However, though the relevance of these studies depends upon human-relevant dosing, surprisingly little is known about THC pharmacology and its effects on behavior and brain activity in adolescent rodents-especially in females. Here, we conducted a systematic investigation of THC pharmacokinetics, metabolism and

SUBMITTER: Ruiz CM 

PROVIDER: S-EPMC8115040 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature