Circulating metabolites and lipids are associated with glycaemic measures in South Asians.

ABSTRACT:

Background

South Asians are at higher risk for diabetes (DM) than many other racial/ethnic groups. Circulating metabolites are measurable products of metabolic processes that may explain the aetiology of elevated risk. We characterized metabolites associated with prevalent DM and glycaemic measures in South Asians.

Methods

We included 717 participants from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study, aged 40-84 years. We used baseline fasting serum for metabolomics and demographic, behavioural, glycaemic data from baseline and at 5 years. We performed LC-MS untargeted metabolomic and lipidomic analysis with targeted integration of known signals. Individual linear and ordinal logistic regression models were adjusted for age, sex, BMI, die

SUBMITTER: Gadgil MD 

PROVIDER: S-EPMC8115216 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature