Deficiency of β-arrestin2 exacerbates inflammatory arthritis by facilitating plasma cell formation.

ABSTRACT: β-arrestin2 (β-arr2) is, a key protein that mediates desensitization and internalization of G protein-coupled receptors and participates in inflammatory and immune responses. Deficiency of β-arr2 has been found to exacerbate collagen antibody-induced arthritis (CAIA) through unclear mechanisms. In this study we tried to elucidate the molecular mechanisms underlying β-arr2 depletion-induced exacerbation of CAIA. CAIA was induced in β-arr2^-/- and wild-type (WT) mice by injection of collagen antibodies and LPS. The mice were sacrificed on d 13 after the injection, spleen, thymus and left ankle joints were collected for analysis. Arthritis index (AI) was evaluated every day or every 2 days. We showed that β-arr2^-/- mice with CAIA had a further increase in the percentage o

SUBMITTER: Zhou WJ 

PROVIDER: S-EPMC8115230 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature