Functional and diffusion MRI reveal the neurophysiological basis of neonates' noxious-stimulus evoked brain activity.

ABSTRACT: Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-individual variability in noxious-stimulus evoked brain activity. We observe that cerebral haemodynamic responses to experimental noxious stimulation can be predicted from separately acquired resting-state brain activity (n = 18). Applying this prediction model to independent Developing Human Connectome Project data (n = 215), we identify negative associations between predicted noxious-stimulus evoked responses and white matter mean diffusivity. These associations are subsequently confirmed in the original noxious stimulation paradigm dataset, validating t

SUBMITTER: Baxter L 

PROVIDER: S-EPMC8115252 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature