MRI-Based Deep-Learning Method for Determining Glioma MGMT Promoter Methylation Status.

ABSTRACT:

Background and purpose

O⁶-Methylguanine-DNA methyltransferase (MGMT) promoter methylation confers an improved prognosis and treatment response in gliomas. We developed a deep learning network for determining MGMT promoter methylation status using T2 weighted Images (T2WI) only.

Materials and methods

Brain MR imaging and corresponding genomic information were obtained for 247 subjects from The Cancer Imaging Archive and The Cancer Genome Atlas. One hundred sixty-three subjects had a methylated MGMT promoter. A T2WI-only network (MGMT-net) was developed to determine MGMT promoter methylation status and simultaneous single-label tumor segmentation. The network was trained using 3D-dense-UNets. Three-fold cross-validation was

SUBMITTER: Yogananda CGB 

PROVIDER: S-EPMC8115363 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature