Preventive effects of influenza and pneumococcal vaccination in the elderly - results from a population-based retrospective cohort study.

ABSTRACT: Influenza and pneumococcal vaccinations are recommended in the elderly to reduce life-threatening complications like sepsis. Protection may be reduced with increasing age. We aimed to assess the effectiveness of both vaccines in the elderly by performing a retrospective cohort study of 138,877 individuals aged ≥60 y in Germany, who were insured in a large statutory health insurance (AOK PLUS). We used longitudinal claims data to classify individuals according to vaccination status 2008-2014, and assessed vaccine effectiveness (VE) in 2015 and 2016. Inverse probability weighting based on generalized propensity scores was used to adjust for systematic between-group differences. Influenza vaccination was associated with a reduction of hospital treatment in laboratory-confirmed influenza in 20

SUBMITTER: Rose N 

PROVIDER: S-EPMC8115600 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature