Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells.

ABSTRACT: Misfolding of the cellular prion protein, PrP^C, into the amyloidogenic isoform, PrP^Sc, which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases. No pathogens other than prions have been identified to induce misfolding of PrP^C into PrP^Sc and propagate infectious prions in infected cells. Here, we found that infection with a neurotropic influenza A virus strain (IAV/WSN) caused misfolding of PrP^C into PrP^Sc and generated infectious prions in mouse neuroblastoma cells through a hit-and-run mechanism. The structural and biochemical characteristics of IAV/WSN-induced PrP^Sc were different from those of RML and 22L laboratory prions-evoked PrP^Sc, and the path

SUBMITTER: Hara H 

PROVIDER: S-EPMC8115602 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature