Metagenomic analysis of mother-infant gut microbiome reveals global distinct and shared microbial signatures.

ABSTRACT: Emerging evidence indicates maternal microbiota as one major reservoir for pioneering microbes in infants. However, the global distinct and identical features of mother-infant gut microbiota at various taxonomic resolutions and metabolic functions across cohorts and potential of infant microbial prediction based on their paired mother's gut microbiota remain unclear. Here, we analyzed 376 mother-infant dyads (468 mother and 1024 infant samples) of eight studies from six countries and observed higher diversity at species and strain levels in maternal gut microbiota but not their metabolic functions. A number of 290 species were shared in at least one mother-infant dyad, with 26 species (five at strain level) observed across cohorts. The profile of mother-infant shared species and strains wa

SUBMITTER: Wang S 

PROVIDER: S-EPMC8115609 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature