Enhanced therapeutic efficacy of Listeria-based cancer vaccine with codon-optimized HPV16 E7.

ABSTRACT: Cervical cancer is a leading cause of high mortality in women in developing countries and has a serious impact on women's health. Human papilloma virus (HPV) prophylactic vaccines have been produced and may hold promise for reducing the incidence of cervical cancer. However, the limitations of current HPV vaccine strategies make the development of HPV therapeutic vaccines particularly important for the treatment of HPV related lesions. Our previous work has demonstrated that LM4Δhly::E7 was safe and effective in inducing antitumor effect by antigen-specific cellular immune responses and direct killing of tumor cell on a cervical cancer model. In this study, the codon usage effect of a novel Listeria-based cervical cancer vaccine LM4Δhly::E7-1, was evaluated for effects

SUBMITTER: Duan F 

PROVIDER: S-EPMC8115762 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature