Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians.

ABSTRACT:

Background

Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors.

Methods

The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Study participants were classified into cardiometabolically healthy and unhealthy, where cardiometabolically healthy were those without hypertension, diabetes, and dyslipidemia. Fasti

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC8115825 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature