Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies.

ABSTRACT: Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatocytes in the human host. This transmission stage has been the subject of many transcriptomics and proteomics studies and is also targeted by the most advanced malaria vaccine. We applied Bayesian data integration to determine which proteins are not only present in sporozoites but are also specific to that stage. Transcriptomic and proteomic Plasmodium data sets from 26 studies were weighted for how representative they are for sporozoites, based on a carefully assembled gold standard for Plasmodium falciparum (Pf) proteins known to be present or

SUBMITTER: Meerstein-Kessel L 

PROVIDER: S-EPMC8115857 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature