Genomic epidemiology of <i>Escherichia coli</i> isolates from a tertiary referral center in Lilongwe, Malawi.

ABSTRACT: Antimicrobial resistance (AMR) is a global threat, including in sub-Saharan Africa. However, little is known about the genetics of resistant bacteria in the region. In Malawi, there is growing concern about increasing rates of antimicrobial resistance to most empirically used antimicrobials. The highly drug resistant Escherichia coli sequence type (ST) 131, which is associated with the extended spectrum β-lactamase blaCTX-M-15, has been increasing in prevalence globally. Previous data from isolates collected between 2006 and 2013 in southern Malawi have revealed the presence of ST131 and the blaCTX-M-15 gene in the country. We performed whole genome sequencing (WGS) of 58 clinical E. coli isolates at Kamuzu Central Hospital, a tertiary care centre in central Mal

SUBMITTER: Tegha G 

PROVIDER: S-EPMC8115906 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature