ActDES - a curated Actinobacterial Database for Evolutionary Studies.

ABSTRACT: Actinobacteria is a large and diverse phylum of bacteria that contains medically and ecologically relevant organisms. Many members are valuable sources of bioactive natural products and chemical precursors that are exploited in the clinic and made using the enzyme pathways encoded in their complex genomes. Whilst the number of sequenced genomes has increased rapidly in the last 20 years, the large size, complexity and high G+C content of many actinobacterial genomes means that the sequences remain incomplete and consist of large numbers of contigs with poor annotation, which hinders large-scale comparative genomic and evolutionary studies. To enable greater understanding and exploitation of actinobacterial genomes, specialized genomic databases must be linked to high-quality genome sequenc

SUBMITTER: Schniete JK 

PROVIDER: S-EPMC8115908 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature