LIM domain only 1: an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types.

ABSTRACT:

Abstract

The LIM domain only 1 (LMO1) gene belongs to the LMO family of genes that encodes a group of transcriptional cofactors. This group of transcriptional cofactors regulates gene transcription by acting as a key "connector" or "scaffold" in transcription complexes. All LMOs, including LMO1, are important players in the process of tumorigenesis. Unique biological features of LMO1 distinct from other LMO members, such as its tissue-specific expression patterns, interacting proteins, and transcriptional targets, have been increasingly recognized. Studies indicated that LMO1 plays a critical oncogenic role in various types of cancers, including T-cell acute lymphoblastic leukemia, neuroblastoma, gastric cancer, lung cancer, and prostate cancer. The molecular mechanisms underlying

SUBMITTER: Zhao GF 

PROVIDER: S-EPMC8116020 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature