Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study.

ABSTRACT:

Background

Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization (MR).

Methods

The MR approach uses a genetic variant as the instrumental variable in epidemiological studies to mimic a randomized controlled trial. A two-sample MR was performed to assess the causal association, using summary statistics from the Atrial Fibrillation Genetics Consortium (n = 537,409) and the Global Lipids Genetics Consortium (n = 188,577). The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and f

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC8116035 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature