Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.

ABSTRACT:

Objective

To characterize endothelial function, inflammation, and immunosuppression in surgical patients with distinct clinical trajectories of AKI and to determine the impact of persistent kidney injury and renal non-recovery on clinical outcomes, resource utilization, and long-term disability and survival.

Summary of background data

AKI is associated with increased healthcare costs and mortality. Trajectories that account for duration and recovery of AKI have not been described for sepsis patients, who are uniquely vulnerable to renal dysfunction.

Methods

This prospective observational study included 239 sepsis patients admitted and enrolled between January 2015 and July 2017. Kidney Disease: Improving Global Outcomes (KDIGO) and Acute Disease Quality Initiative (AD

SUBMITTER: Ozrazgat-Baslanti T 

PROVIDER: S-EPMC8116352 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature