Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study.

ABSTRACT:

Objective

To estimate the real world effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19 symptoms (including the UK variant of concern B.1.1.7), admissions to hospital, and deaths.

Design

Test negative case-control study.

Setting

Community testing for covid-19 in England.

Participants

156 930 adults aged 70 years and older who reported symptoms of covid-19 between 8 December 2020 and 19 February 2021 and were successfully linked to vaccination data in the National Immunisation Management System.

Interventions

Vaccination with BNT162b2 or ChAdOx1-S.

Main outcome measures

Primary outcomes were polymerase chain reaction confirmed symptomatic SARS-CoV-2 infections, admissions to hospital f

SUBMITTER: Lopez Bernal J 

PROVIDER: S-EPMC8116636 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature