Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-Sequencing.

ABSTRACT: A chronic inability to maintain blood glucose homeostasis leads to diabetes, which can damage multiple organs. The pancreatic islets regulate blood glucose levels through the coordinated action of islet cell-secreted hormones, with the insulin released by β-cells playing a crucial role in this process. Diabetes is caused by insufficient insulin secretion due to β-cell loss, or a pancreatic dysfunction. The restoration of a functional β-cell mass might, therefore, offer a cure. To this end, major efforts are underway to generate human β-cells de novo, in vitro, or in vivo. The efficient generation of functional β-cells requires a comprehensive knowledge of pancreas development, including the mechanisms driving cell fate decisions or endocrine cell maturation. Rapid progress in

SUBMITTER: Szlachcic WJ 

PROVIDER: S-EPMC8116659 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature