Epigenomics, genomics, resistome, mobilome, virulome and evolutionary phylogenomics of carbapenem-resistant Klebsiella pneumoniae clinical strains.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) remains a major clinical pathogen and public health threat with few therapeutic options. The mobilome, resistome, methylome, virulome and phylogeography of CRKP in South Africa and globally were characterized. CRKP collected in 2018 were subjected to antimicrobial susceptibility testing, screening by multiplex PCR, genotyping by repetitive element palindromic (REP)-PCR, plasmid size, number, incompatibility and mobility analyses, and PacBio's SMRT sequencing (n=6). There were 56 multidrug-resistant CRKP, having bla_OXA-48-like and bla_NDM-1/7 carbapenemases on self-transmissible IncF, A/C, IncL/M and IncX₃ plasmids endowed with prophages, traT, resistance islands, and type I

SUBMITTER: Kopotsa K 

PROVIDER: S-EPMC8116673 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature