Evidence of homologous recombination as a driver of diversity in Brachyspira pilosicoli.

ABSTRACT: The enteric, pathogenic spirochaete Brachyspira pilosicoli colonizes and infects a variety of birds and mammals, including humans. However, there is a paucity of genomic data available for this organism. This study introduces 12 newly sequenced draft genome assemblies, boosting the cohort of examined isolates by fourfold and cataloguing the intraspecific genomic diversity of the organism more comprehensively. We used several in silico techniques to define a core genome of 1751 genes and qualitatively and quantitatively examined the intraspecific species boundary using phylogenetic analysis and average nucleotide identity, before contextualizing this diversity against other members of the genus Brachyspira. Our study revealed that an additional isolate that was unable t

SUBMITTER: Pandey A 

PROVIDER: S-EPMC8116685 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature